Don Moore was the writer of the Flash Gordon, taking over scriptwriting duties from strip creator Alex Raymond in August 1935. Moore was a former pulp editor. Raymond was the creator of several strips at the time; Flash Gordon, Secret Agent X-9, Jungle Jim; and needed Moore's scripting assistance.

After working for a while at advertising agency, he became an assistant to the cartoonist Alex Raymond on Flash Gordon and succeeded him on Secret Agent Corrigan. In 1940 he drew a Flash Gordon Daily strip which he stayed on until about 1944. He drew the prestigious Flash Gordon Sunday strip from 1944 until 1948. He was one of the founding faculty for the Famous Artists School. In 1969 he was elected to the Society of Illustrators’ Hall of Fame.