High school students heroic act turns into epic human vs. monster sword fight!

Buso Renkin is the story of teenager Kazuki Muto, who dies trying to save a girl who was being attacked by an eerie monster. The next morning, however, Kazuki is left wondering whether it was all a dream. Lo and behold, the girl, the monster, and his death are all real! The girl, Tokiko Tsumura, was actually trying to slay the homunculus (a beast that can take the form of humans, and whose main source of food is people), but Kazuki got in her way. To revive Kazuki, Tokiko replaces his heart with a "kakugane," an alchemic device that allows him to summon a lance with which to fight the monsters. It turns out that Tokiko is a member of the Alchemist Warriors, an organization sworn to protect the world from the diabolical creatures. Soon, Kazuki joins Tokiko in her quest to terminate the sinister being that creates and controls the homunculus.

Kazuki and Tokiko are on the run from the hunters of the Alchemist Warriors! Tokiko, now reduced to the size of a doll, fights alongside Kazuki and Gouta as they take on three of the hunters and Captain Bravo himself, whose past is finally revealed! As Kazuki and Captain Bravo's battle draws to a close, another Warrior Chief appears, as well as a man calling himself the Great Warrior Chief. What will it mean for Kazuki and his friends?